The Carb-Sane Asylum: Does insulin block leptin in the brain?
There are two key hormones that regulate food intake and energy balance: the adipocyte hormone leptin and the pancreatic hormone insulin. PDF | Objectives: To assess sex hormones, leptin and insulin-resistance in men with prostate cancer (PCa) and benign prostatic hyperplasia. - The association between leptin and insulin levels in adults with cystic fibrosis La relation entre l'insuline et la leptine chez les adultes atteints de et d'insuline (AUC0− et AUC30−) même après ajustement pour le sexe et la.
Prevalence of hyperleptinemia was Serum leptin levels were positively correlated with IR, which was significant among the Class III morbid obesity class. However, leptin was not a predictive factor for IR in obese Nigerian women.
Introduction Obesity, an increase in body fat mass, is one of the leading preventable causes of death worldwide. In Nigeria, adult obesity prevalence rates of Insulin stimulates production of leptin when adipocytes are exposed to glucose to encourage satiety; while leptin, via a negative feedback, decreases the secretion of insulin and enhances tissue sensitivity to it, leading to glucose uptake for energy utilization or storage.
Consequently, the aim of this study was to determine the relationship between leptin and IR among obese Nigerian women.
Informed consent was obtained from each participant. By design, all CF glucose tolerance groups had different mean 2-h glucose values. As expected, CF patients exhibited lower early-phase insulin secretion AUC0—30 than the control subjects.
Associations between leptin and insulin are presented in Table 3.
The association between leptin and insulin levels in adults with cystic fibrosis - EM|consulte
On the other hand, there were no associations between leptin and glucose values from the OGTT fasting glucose, 2-h glucose and glucose AUC0— and fibrinogen data not shown. Discussion Despite reduced insulin levels and contrary to our hypothesis, our studied CF adults displayed leptin levels comparable to those of their healthy counterparts. There was also a positive association between leptin and insulin levels during an oral glucose challenge in stable CF adults with moderate disease.
Leptin beyond body weight regulation: Leptin at 14 years of age: Dopamine is known to be involved in wakefulness and one requires a minimum level of dopamine activity to be alert. The condition of "adhd" is treated with dopaminergic stimulants which really often just glucose intolerance dopamine receptor downreguation and so one cannot focus or stay alert. However there is a critical threshhold of dopamine that promotes sleep and dreaming.
Relationship between serum leptin and insulin resistance among obese Nigerian women
Taking a stimulant dopaminergic will keep you alert and awake, but wouldn't you be surprised to find out that parkinson's patients cannot sleep AT ALL and cannot dream? I would hope a doctor of obesity research would be more familiar with physiology and would know understand that one cannot automatically assume the same endocrine signal has a linear effect at high and low intensities.
Our endocrine and nervous system was designed by evolution to capitalize or respond to environment. Hypoinsulinemia is a radically different condition than hyperinsulinemia so do not be surprised if our physiology treats them as such.
Hypoinsulinemia suggets starvation and hyperinsulinemia suggests seasonal nutritional excess. CarbSane I think this paper should help you out a bit. Its full free text.
If NIRKO mice are fat it could be because Agrp insulin receptor knock-out means you fail to suppress hepatic glucose production on that yummy chow. Evelyn aka CarbSane said Thanks for weighing in here Stephan. I have other interests at the moment so I thought I'd put this out there rather than sorting through the literature myself. That was a great post by Chris. The fact that insulin resistance is not found in all obese people does not mean it plays no causal role, because obesity does not necessarily have the same cause in every person.
Put that paper in the Library for another day too.